This study determined the effect of an integrated exercise program (coach and family) in three children with Down syndrome to Betterment their motor and cognitive capabilities, especially reaction time and working memory. For this purpose, the integrated exercise training program was applied in three children with Down syndrome, containing two boys (M1, with a chronologic age of 10.3 years and a mental age of 4.7 years M2, with a chronologic age of 14.6 years and a mental age of less than 4 years) and one girl (F1, chronologic age 14.0 years and a mental age of less than 4 years). Betterments in gross motor capability scores were seen after the training period and Greater Betterments in reaction time test were observed for evaluation parameters. There is a near interrelationship between motor and cognitive areas in subjects with uncommon growth. So, there is a requirement to design intervention programs based on the synchronous involvement of child and parents and aimed at promoting an active lifestyle in subjects with Down syndrome.